I was reading a recent report related to research initiatives throughout the European Union related to ‘Getting to the source of what makes us human’ (ISBN 92-79-03833-8), and I wanted to bring it to the attention of all rationalists. The full report can be found here.
What has surprised me is how many European institutions are getting left behind in leading-edge research. Certainly, the initiative has had advantages in terms of collaboration between various centers of excellence throughout Europe, and the commission money has been forthcoming on many research topics. My argument has always been to build on leading edge research – wherever it is based. I am surprised that many universities are researching subjects where many of the conclusions are already available.
…So What Makes us Human?
How and why are humans different? What features make our cognitive facilities unique and what are the origins of these features? The focal questions behind the NEST Pathfinder initiative, What it Means to Be Human, foster cross-disciplinary research projects that bring to bear the latest insights from fields including genetics, biology, neuroscience, psychology, linguistics and anthropology to help generate answers for one of science’s most elusive subjects.
The questions are scientifically precise and limited, but can be addressed from a number of disciplinary angles. In particular, What it Means to Be Human aims to address:
- the evolutionary dimension of individual development as regards to human cognitive faculties, taking account of the range of relevant factors from genetics to cultural context;
- the influence of change of life circumstances on the development of cognitive functions, such as the development of language and non-verbal communication;
- executive functions, reasoning and decision-making, including cooperative behaviour, which might also take account of relationships between conscious and unconscious aspects of behaviour.
With its common values, varied cultures, and strong research tradition in many of the relevant fields, Europe has a vital interest in this area and real potential for fostering scientific progress. This progress would have considerable future benefits. By understanding the specific nature and limits of human conceptual reasoning, for example, it would be possible to devise more powerful artificial learning technologies. Improved education strategies could be developed as a result of further knowledge of specifically human capabilities to perceive and encode information and experience. Furthermore, greater insight into the origins of human motivation, social behaviour and cooperation would assist the design of social and cultural institutions to accommodate human needs in better ways.
This global understanding of the human mind is clearly a very long way off. However, in order to move forward, there is a crucial need for interdisciplinary work to generate concepts that make sense not only at a particular level of analysis, but also within a broader ‘system of understanding’ that encompasses these different levels. For example, if the links between genetics and mental faculties are to be understood, there will be a need to find categories for defining behavioural phenomena which allow them to be linked to genetic factors, and vice versa.
This need for interdisciplinary work is all the more pressing because of the very rapid pace of developments in the various relevant fields, in particular biology and genomics. The ‘What it Means to Be Human’ initiative offers the ideal, productive arena for this interdisciplinary research.
Exploring the Origins of the Human Mind
Our advanced ability to think, to express emotions and to influence the behaviour of those around us is part of what makes the human mind unique. These higher cognitive functions have evolved through major changes in the structure, functional complexity and size of the brain at different points along the evolutionary tree that links us to monkeys and apes. Identifying the molecular basis for these changes is key to understanding which cognitive abilities, and their corresponding genes, are unique to humans.
The NEST PKB140404 project, part of the PATHFINDER initiative to investigate ‘What it means to be human’, will use an integrated approach, bridging cognitive neuroscience and molecular evolution, to probe the differences between the brains of humans and their closest relatives, the apes. The consortium’s multidisciplinary research teams, combining skills in molecular and evolutionary biology, bioinformatics, clinical psychiatry and neuroscience, aim to reconstruct the history of the evolutionary changes that led to the emergence of the human mind as it is today. In a three-pronged approach, each team will look for turning points in the development of the human mind by studying different stages in the molecular process.
Pinpointing molecular change The Swiss group will search for recently evolved genes that have arisen through retroposition – a type of gene duplication – and that are associated with cognitive abilities. A burst of retroposition started around the time when the group comprising humans, apes and Old World monkeys branched off on the evolutionary tree. Some of the new genes created by this evolutionary process enabled new neurological functions and resulted, through positive selection, in the development of higher cognitive abilities. The German group will use advanced micro-array technology to scan genes shared by humans and apes to look for those expressed differently in each species’ brain. As some differences in expression can lead to changes in gene function, the project’s challenge is to identify which of these differences are associated with changes in cognitive ability and whether they could be responsible for the human brain’s uniqueness.
A third approach, by the British group, will identify which genes dysfunction in human diseases like schizophrenia, by comparing post-mortem brain samples taken from schizophrenia patients with those from a healthy control group, and with those from the corresponding region of the ape brain. Schizophrenia is characterised by a reduced ability to understand and manipulate the mental representations of others. As this and other cognitive abilities affected by the disease are less developed or not present in apes, it is likely that the human genes associated with schizophrenia play a pivotal role in human cognition.
Setting us apart
This project has the potential to unravel several of the mysteries surrounding the birth of the human mind, by revealing and dating some of the genetic changes that have contributed to our shared heritage and set us apart from other species. An important step in validating the project’s findings will be confirming the function of the candidate human cognition genes identified by the three complementary approaches. To do this, the consortium will carry out in vivo studies using transgenic mice carrying the human gene and compare their resulting phenotypes with mice carrying an equivalent gene from the ape genome.
In the long term, they hope to show that replacing a sufficiently large number of mouse genes with their human counterparts will lead to altered behaviour in the mice and provide further insights into genetically regulated human cognitive faculties. This ambitious reconstruction of the evolutionary history of human cognitive abilities will set the standards for new work in the area. The consortium will explore new horizons in cognitive science and should make an important contribution to solving the enigma of human nature.
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